Novel Non-Toxic Highly Antibacterial Chitosan/Fe(III)-Based Nanoparticles That Contain a Deferoxamine—Trojan Horse Ligands: Combined Synthetic and Biological Studies

In this study, we prepared chitosan/Fe(III)/deferoxamine nanoparticles with unimodal size distribution (hydrodynamic diameter ca. 250 nm, zeta potential 32 mV). The elaborated are characterized by outstanding in vitro and vivo antibacterial activity, which exceeds even that of commercial antibiotics ampicillin gentamicin. Moreover, the non-toxic. We found introduction iron ions into chitosan matrix increases ability resulting to disrupt integrity membranes microorganisms comparison pure chitosan. deferoxamine obtained sharply expands their effect destruction bacterial membrane. promising for further preclinical studies.